관리 메뉴

redGen's story

DM 치료의 혈당강화효과 비교 본문

Medical archive

DM 치료의 혈당강화효과 비교

재도담 2017. 3. 14. 08:08

How much lowering of glycosylated hemoglobin (HbA1c) levels should we expect when we prescribe metformin to patients with diabetes? To answer this question, researchers performed a meta-analysis of 35 randomized metformin trials of ≥12 weeks' duration. Key findings are as follows:

  • In comparisons between metformin monotherapy and placebo (or no drug treatment), metformin reduced mean HbA1c level by 1.1%.

  • In comparisons involving metformin plus another oral agent versus the other agent alone, addition of metformin reduced mean HbA1c level by 1.0%.

  • In comparisons involving metformin plus insulin versus insulin alone, addition of metformin reduced mean HbA1c level by 0.8% in patients with type 2 diabetes. In patients with type 1 diabetes receiving insulin, add-on metformin therapy had no HbA1c-lowering effect.

  • In comparisons between low-dose and high-dose metformin (usually 1000 vs. 2000 mg daily), HbA1clevel was 0.3% lower with high-dose therapy.


quantifying the effect of metformin treatment and dose on glycemic control.pdf


DPP-IV inhibitor는 HbA1c 0.8% 정도 떨어뜨림. 





'Medical archive' 카테고리의 다른 글

New Hypertension Guideline  (0) 2018.03.15
천식 진료지침 (2016 개정판)  (0) 2018.03.05
2017 내과전문의 평생교육 연수강좌  (0) 2017.03.13
Echocardiography  (0) 2016.11.27
Bundle branch block  (0) 2015.08.21